FOXO4-DRI · CAS 2173226-03-2
FOXO4-DRI 10mg
FOXO4-DRI is a D-amino acid retro-inverso peptide designed to disrupt the FOXO4-p53 protein-protein interaction that protects senescent cells from apoptosis. Dasatinib et al. 2017 Nature Medicine demonstrated selective clearance of p16-positive senescent cells in aged mice. 98.7% HPLC purity.
Shop This CompoundFor laboratory research use only. Not for human consumption. Not FDA-approved for any use.
Material Specifications — FOXO4-DRI 10mg
- Vial Size
- 1mg
- Form
- Lyophilized Powder
- Purity
- 98.7% HPLC
- CAS
- 2173226-03-2
- Storage
- -20C long-term
Research Questions Answered — FOXO4-DRI 10mg
What is the senolytic mechanism of FOXO4-DRI?+
Senescent cells survive via FOXO4-p53 binding in the nucleus. FOXO4-DRI disrupts this interaction, allowing p53 to activate its canonical apoptotic pathway specifically in senescent cells while sparing normal cells.
Mode of Action — FOXO4-DRI
Competes with endogenous FOXO4 for p53 binding in senescent cells, displacing the survival signal that prevents senescent cell apoptosis. Selectively targets cells with high nuclear FOXO4 expression — a hallmark of the SASP-secreting senescent phenotype.
